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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61490 | P2X receptor-1 | ||
P2X receptor-1 is a potential inhibitor of P2X receptor for the treatment of pain and inflammation. | |||
T4S0536 | Bullatine A | Apoptosis , P2X Receptor | |
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treatment of neurodegenerative diseases such as arthritis. | |||
T8946 | Indophagolin | P2X Receptor , 5-HT Receptor , Autophagy | |
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. | |||
T22518 | 5-BDBD | P2X Receptor | |
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG. | |||
T10207 | A 438079 | P2X Receptor | |
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9). | |||
T10466 | BAY-1797 | P2X Receptor | |
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels. | |||
T3690 | A-740003 | A 740003 | P2X Receptor |
A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuro... | |||
T3639 | A-804598 | A 804598 | P2X Receptor |
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). | |||
T5513 | RO-3 | P2X Receptor | |
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor | |||
T9833 | Opiranserin hydrochloride | P2X Receptor , GlyT , 5-HT Receptor | |
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50... | |||
T14385 | AZD9056 hydrochloride | P2X Receptor | |
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation. | |||
T9519 | Eliapixant | BAY 1817080 | P2X Receptor |
Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough. | |||
T2087 | AF-353 | Ro-4 | P2X Receptor |
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0). | |||
T14844 | BX430 | P2X Receptor , Calcium Channel | |
BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. | |||
T8333 | Aurintricarboxylic acid | ATA,NSC-4056,NSC4056,NSC 4056 | Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase |
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. | |||
T4298 | JNJ-47965567 | JNJ-479655 | P2X Receptor |
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively). | |||
T40045 | Sivopixant | S-600918,Sivopixant | P2X Receptor |
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect . | |||
T12568 | PSB-12062 | N-(p-Methylphenylsulfonyl)phenoxazine | P2X Receptor |
PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4). | |||
T14920 | CE-224535 | PF-04905428 | P2X Receptor |
CE-224535 (PF-04905428) is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies. | |||
T14366 | AZ10606120 dihydrochloride | P2X Receptor | |
AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and ... |